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Trends Cell Biol. 2001 Sep;11(9):353-8.

Alternative splicing of potassium channels: a dynamic switch of cellular excitability.

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Membrane Biology Group, Section of Biomedical Science, University of Edinburgh Medical School, Hugh Robson Building, EH8 9XD, Edinburgh, UK.


Alternative splicing of pre-messenger RNA and reversible protein phosphorylation are fundamental mechanisms for regulating protein structure and function. Recent studies of one class of potassium channel (BK(Ca)) reveal dynamic reciprocal interactions between pre-mRNA splicing and protein phosphorylation. Splicing is regulated by phosphorylation, and exon selection determines the sensitivity of the channel protein to regulation by protein phosphorylation. These studies reveal a powerful dynamic molecular switch to determine cellular excitability.

[Indexed for MEDLINE]

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