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Bioorg Med Chem Lett. 2001 Aug 20;11(16):2061-5.

1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI).

Author information

1
GlaxoSmithKline Pharmaceuticals, Antibacterials and Host Defense, 1250 S. Collegeville Road, Collegeville, PA 19426, USA. dirk_a_heerding@sbphrd.com

Abstract

1,4-Disubstituted imidazole inhibitors of Staphylococcus aureus and Escherichia coli enoyl acyl carrier protein reductase (FabI) have been identified. Crystal structure data shows the inhibitor 1 bound in the enzyme active site of E. coli FabI.

PMID:
11514139
DOI:
10.1016/s0960-894x(01)00404-8
[Indexed for MEDLINE]

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