Format

Send to

Choose Destination
Peptides. 2001 Sep;22(9):1439-46.

The capsaicin VR1 receptor mediates substance P release in toxin A-induced enteritis in rats.

Author information

1
Department of Cell Biology, Box 3709, Duke University Medical Center and Durham V. A. Medical Center, Durham, North Carolina 27710, USA.

Abstract

The mechanism by which Clostridium difficile toxin A causes substance P (SP) release and subsequent inflammation in the rat ileum is unknown. Pretreatment with the vanilloid receptor subtype 1 (VR1) antagonist, capsazepine, before toxin A administration significantly inhibited toxin A-induced SP release and intestinal inflammation. Intraluminal administration of the VR1 agonist capsaicin caused intestinal inflammation similar to the effects of toxin A. Pretreatment with capsazepine before capsaicin administration also significantly inhibited capsaicin-induced intestinal inflammation. These results suggest that intraluminal toxin A causes SP release from primary sensory neurons via stimulation of VR1 receptors resulting in intestinal inflammation.

PMID:
11514026
DOI:
10.1016/s0196-9781(01)00463-6
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center