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FEBS Lett. 2001 Aug 10;503(1):1-6.

Expansion of the zinc metallo-hydrolase family of the beta-lactamase fold.

Author information

1
Department of Bioinformatics, Biomolecular Engineering Research Institute, Osaka, Japan.

Abstract

Recently, the zinc metallo-hydrolase family of the beta-lactamase fold has grown quite rapidly, accompanied by the accumulation of sequence and structure data. The variety of the biological functions of the family is higher than expected. In addition, the members often have mosaic structures with additional domains. The family includes class B beta-lactamase, glyoxalase II, arylsulfatase, flavoprotein, cyclase/dehydrase, an mRNA 3'-processing protein, a DNA cross-link repair enzyme, a DNA uptake-related protein, an alkylphosphonate uptake-related protein, CMP-N-acetylneuraminate hydroxylase, the romA gene product, alkylsulfatase, and insecticide hydrolases. In this minireview, the functional and structural varieties of the growing protein family are described.

PMID:
11513844
DOI:
10.1016/s0014-5793(01)02686-2
[Indexed for MEDLINE]
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