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Can J Neurol Sci. 2001 Aug;28(3):232-8.

Methodology for the Canadian Activase for Stroke Effectiveness Study (CASES). CASES Investigators.

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Department of Clinical Neurosciences, University of Calgary, Foothills Medical Centre, AB, Canada.

Erratum in

  • Can J Neurol Sci 2002 Feb;29(1):103.



Intravenous recombinant tissue plasminogen activator (tPA, alteplase) was conditionally licensed for the treatment of acute ischemic stroke (AIS) in Canada on February 17, 1999. As a condition of licensure, the Canadian Activase for Stroke Effectiveness Study (CASES) was established to monitor the use of alteplase for AIS in Canada. The study involves multiple stakeholders.


CASES is a prospective registry of patients treated with alteplase for AIS. The purposes of this registry are to ensure the safety of the drug in the Canadian context, to assess effectiveness of alteplase for AIS and to gather further information to try to establish which patients are most likely to benefit from treatment.


Both community (n=25) and tertiary centres (n=35) have enrolled a total of 944 patients to date. Early results suggest that thrombolytic stroke treatment is both safe and effective among these centres.


This paper outlines the development of and methods for the CASES study. The study is an example of a multi-stakeholder collaboration to advance the care of patients with acute stroke.

[Indexed for MEDLINE]

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