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J Acquir Immune Defic Syndr. 2001 Aug 15;27(5):417-25.

Dendritic cells transduced with HIV Nef express normal levels of HLA-A and HLA-B class I molecules.

Author information

1
Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599-7290, USA.

Abstract

HIV Nef protein is important for viral pathogenesis and disease progression. Nef downregulates CD4 and major histocompatibility antigens on the surface of HIV-infected T cells. HIV also infects dendritic cells. We wanted to determine if Nef had a similar function in professional antigen-presenting cells, where downregulation of Class I could have important effects on the initiation of HIV specific cytolytic T cell responses. We infected human dendritic cells with adenovirus expressing Nef. In contrast to T cells and Hela cells, HLA-A and HLA-B molecules are not downregulated nor are other class I molecules increased. We show that, in dendritic cells, HIV Nef has little effect on CD4 or Class I expression.

[Indexed for MEDLINE]

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