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Arch Orthop Trauma Surg. 2001 Jul;121(7):426-8.

The contribution of vitamin C to healing of experimental fractures.

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Department of Orthopaedics and Traumatology, University of Ankara Medical School, Turkey.


The benefits of various minerals and vitamins on fracture healing have been demonstrated in animal models. Vitamin C is an essential substance in fracture healing but has not been studied previously on an experimental basis. Sixteen rats were grouped randomly into control and vitamin C-supplemented groups. The right tibias of all rats were fractured by digital manipulation. One group received single high dose of vitamin C intramuscularly. On the 5th, 10th, 15th, and 20th days, two rats from each group were killed and the tibias examined under light microscopy. It was seen that the vitamin C-supplemented group went through the stages of fracture healing faster compared with the control group.

[Indexed for MEDLINE]

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