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Planta Med. 2001 Aug;67(6):585-7.

A new guaianolide as apoptosis inhibitor from Chrysanthemum boreale.

Abstract

The 8-O-acetyl-3,10-dihydroxy-4(15),11(13)-guaiadien-12,6-olide, named borenolide, was isolated from Chrysanthemum boreale M. Borenolide inhibits the etoposide-induced apoptosis in U937 cell with an IC(50) value of 6.2 microg/ml. Structural assignment was based on NMR-spectroscopic methods and X-ray crystallographic analysis.

PMID:
11509991
DOI:
10.1055/s-2001-16477
[Indexed for MEDLINE]
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