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BMJ. 2001 Aug 18;323(7309):369.

Maternal and paternal age at delivery, birth order, and risk of childhood onset type 1 diabetes: population based cohort study.

Author information

1
Diabetes Research Centre, Aker and Ullevål University Hospitals, Department of Paediatrics, Ullevål Hospital, N-0407 Oslo, Norway. lars.christian.stene@folkehelsa.no

Abstract

OBJECTIVE:

To estimate the associations of maternal and paternal age at delivery and of birth order with the risk of childhood onset type 1 diabetes.

DESIGN:

Cohort study by record linkage of the medical birth registry and the national childhood diabetes registry in Norway.

SETTING:

Norway.

SUBJECTS:

All live births in Norway between 1974 and 1998 (1.4 million people) were followed for a maximum of 15 years, contributing 8.2 million person years of observation during 1989-98. 1824 cases of type 1 diabetes diagnosed between 1989 and 1998 were identified.

MAIN OUTCOME MEASURES:

Incidence of type 1 diabetes.

RESULTS:

There was no association between maternal age at delivery and type 1 diabetes among firstborn children, but among fourth born children there was a 43.2% increase in incidence of diabetes for each five year increase in maternal age (95% confidence interval 6.4% to 92.6%). Each increase in birth order was associated with a 17.9% reduction in incidence (3.2% to 30.4%) when maternal age was 20-24 years, but the association was weaker when maternal age was 30 years or more. Paternal age was not associated with type 1 diabetes after maternal age was adjusted for.

CONCLUSIONS:

Intrauterine factors and early life environment may influence the risk of type 1 diabetes. The relation of maternal age and birth order to risk of type 1 diabetes is complex.

PMID:
11509426
PMCID:
PMC37395
[Indexed for MEDLINE]
Free PMC Article
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