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Phytother Res. 2001 Aug;15(5):441-3.

Cytotoxic coumarins and lignans from extracts of the northern prickly ash (Zanthoxylum americanum).

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  • 1Department of Plant Science, Cook College, Rutgers University, New Brunswick, NJ 08903, USA.


Four pyranocoumarins; dipetaline, alloxanthoxyletin, xanthoxyletin and xanthyletin; and two lignans; sesamin and asarinin were isolated from the northern prickly ash, Zanthoxylum americanum. To varying degrees, all inhibited the incorporation of tritiated thymidine into human leukaemia (HL-60) cells. Dipetaline was the most active with an IC(50) of 0.68 ppm, followed by alloxanthoxyletin (1.31 ppm), sesamin (2.71 ppm), asarinin (4.12 ppm), xanthoxyletin (3.48 ppm) and xanthylletin (3.84 ppm).

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