Format

Send to

Choose Destination
Br J Cancer. 2001 Aug 17;85(4):518-22.

IL-6 gene amplification and expression in human glioblastomas.

Author information

1
Centre Jean Perrin, 58 rue Montalembert, 63011 Clermont-Ferrand, France.

Abstract

The aggressiveness of human gliomas appears to be correlated with the upregulation of interleukin 6 (IL-6) gene. Using quantitative PCR methods, we detected amplification and expression of the IL-6 gene in 5 of 5 primary glioblastoma samples and in 4 of 5 glioblastoma cell lines. This finding suggests that the amplification of IL-6 gene may be a common feature in glioblastomas and may contribute to the IL-6 over-expression.

PMID:
11506489
PMCID:
PMC2364101
DOI:
10.1054/bjoc.2001.1942
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center