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Trends Biochem Sci. 2001 Aug;26(8):468-9.

Sialic acid synthase: the origin of fish type III antifreeze protein?

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  • 1Dept of Biochemistry, Queen's University, ON, K7L 3N6, Kingston, Canada.


Fish type III antifreeze protein is homologous to the C-terminal region of mammalian sialic acid synthase. Similarity is greatest in the protein core and the flat ice-binding region. This relationship adds to the growing list of links between ice-binding proteins (antifreezes) and proteins that interact with sugars and polysaccharides.

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