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Drug Resist Updat. 1999 Feb;2(1):3-8.

The IGF/IGF-1 receptor signaling pathway as a potential target for cancer therapy.

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1
Research Institute of Molecular Pathology, Vienna, Austria

Abstract

Expression of insulin-like growth factors (IGFs) and their cognate receptor, the IGF-1 receptor, is frequently upregulated during the development of many types of cancer. Besides stimulating cell cycle progression and the transformation status of tumor cells, a wealth of recent experimental data suggests that IGF-mediated signaling exerts a central tumor-promoting function through the repression of tumor cell apoptosis. These functions are all conveyed by the IGF-1 receptor, thus making it an attractive target for therapeutic intervention. Notably, inhibition of IGF-mediated survival function appears to synergize with conventional chemotherapeutic ablation of tumor cells, raising the possibility of combinatorial cancer therapies with significantly reduced side-effects.

PMID:
11504463
DOI:
10.1054/drup.1998.0061

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