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J Perinatol. 2001 Apr-May;21(3):156-60.

Focal small bowel perforation: an adverse effect of early postnatal dexamethasone therapy in extremely low birth weight infants.

Author information

1
Department of Pediatrics, University of North Carolina at Chapel Hill, 27599-7596, USA.

Abstract

OBJECTIVE:

We tested the hypothesis that early postnatal dexamethasone (EPD) increases the risk of focal small bowel perforation (FSBP) in extremely low birth weight (ELBW) infants.

STUDY DESIGN:

The techniques of meta-analysis were applied to studies evaluating EPD, which we identified through a systematic literature search. Studies were included if they were randomized, placebo-controlled trials of EPD, enrolled infants with birth weights < or =1000 g, and reported FSBP as an outcome variable. The Breslow-Day test was used to assess for homogeneity and a summary odds ratio was calculated using the Mantel-Haenszel exact method.

RESULTS:

Four studies, with a pooled sample of 1383 infants, were included in the primary analysis. The Breslow-Day test showed a p-value of 0.61, indicating homogeneity among the studies. FSBP was significantly higher in EPD treated infants [odds ratio 1.91, 95% confidence interval (CI) 1.21, 3.07; p=0.004].

CONCLUSION:

EPD increases the risk of FSBP in ELBW infants.

PMID:
11503101
DOI:
10.1038/sj.jp.7200520
[Indexed for MEDLINE]
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