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Neurology. 2001 Aug 14;57(3):548-50.

A prospective natural history study of inclusion body myositis: implications for clinical trials.

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  • 1Department of Neurology, King's Neurosciences Centre, King's College Hospital, London, UK.


Eleven patients with untreated inclusion body myositis (IBM) were prospectively studied during a 6-month period that included muscle strength, lean body mass, and muscle mass measurements. There was an overall quantifiable mean decline in percent of predicted normal muscle strength of 4% from baseline in a 6-month period, but one third of patients showed no change or slight improvements in strength. Short-term treatment trials in IBM will require large numbers of patients to detect slowing, arrest, or even slight improvement in muscle strength.

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