Format

Send to

Choose Destination
J Mammary Gland Biol Neoplasia. 2001 Apr;6(2):235-43.

Loss of chromosomal integrity in human mammary epithelial cells subsequent to escape from senescence.

Author information

1
Department of Pathology, University of California at San Francisco, 94143-0506, USA. ttlsty@itsa.icsf.edu
2
U CA, San Francisco

Abstract

The genomic changes that foster cancer can be either genetic or epigenetic in nature. Early studies focused on genetic changes and how mutational events contribute to changes in gene expression. These point mutations, deletions and amplifications are known to activate oncogenes and inactivate tumor suppressor genes. More recently, multiple epigenetic changes that can have a profound effect on carcinogenesis have been identified. These epigenetic events, such as the methylation of promoter sequences in genes, are under active investigation. In this review we will describe a methylation event that occurs during the propagation of human mammary epithelial cells (HMEC) in culture and detail the accompanying genetic alterations that have been observed.

PMID:
11501583
DOI:
10.1023/a:1011369026168
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center