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Yao Xue Xue Bao. 1997 Apr;32(4):278-81.

[Total synthesis of nordihydroguaiaretic acid].

[Article in Chinese]

Author information

1
Department of Chemistry, National Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000.

Abstract

beta-Keto ester(5) was obtained from vanilin through etherification, oxidation and condensation with acetoacetic ester, (5) on oxidative coupling reaction by NaOEt/I2 produced dimer (6) in high yield. Acid catalyzed cyclodehydration of (6) gave the furan derivative(7), and by a series of selective hydrogenation nordihydroguaiaretic acid, furoguaiacin dimethyl ether and dihydroguaiaretic acid dimethyl ether were synthesized.

PMID:
11499030
[Indexed for MEDLINE]

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