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Drug Resist Updat. 2000 Apr;3(2):109-125.

b-Lactamase inhibitors.

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1
Pharma Division, Preclinical Research, F. Hoffmann-La Roche Ltd, Basel, CH-4070, Switzerland

Abstract

The use of beta-lactamase inhibitors in combination with a beta-lactamase-susceptible antibiotic is a useful strategy to rescue otherwise good antibiotics from failure. However, recent years have seen a rise in the numbers of beta-lactamases that are insensitive to the available beta-lactamase inhibitors. This review summarizes of the mechanisms of action of the principal types of inhibitors and the ways in which beta-lactamase are thought to develop resistance towards them. Ten general classes of inhibitors are reviewed, especially those of therapeutic importance (clavulanic acid, penam sulfones and carbapenems).

PMID:
11498375
DOI:
10.1054/drup.2000.0137

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