Format

Send to

Choose Destination
See comment in PubMed Commons below
Drug Resist Updat. 2000 Feb;3(1):7-13.

Hypoxic cytotoxic agents: a new approach to cancer chemotherapy.

Author information

1
Department of Radiation Oncology, Stanford University, Stanford, CA, 94305, USA

Abstract

Many of the cells in solid tumors are hypoxic. This makes them resistant to killing by both radiotherapy and most commonly used anticancer drugs. The resistance towards anticancer drugs is because hypoxia induces a non-proliferative state as well as the fact that the hypoxic cells are furthest from the blood vessels in the tumor (and hence the source of drug). However, a new class of drugs - hypoxic cytotoxins can, by killing these hypoxic cells, not only overcome this resistance, but also exploit hypoxia thereby converting it into a therapeutic advantage. The first drug to be tested in the clinic purely for its activity towards hypoxic cells, tirapazamine, is described.

PMID:
11498360
DOI:
10.1054/drup.2000.0120
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center