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J Clin Anesth. 2001 Aug;13(5):370-3.

A study of 13 patients with gastric tube in place after esophageal resection: use of omeprazole to decrease gastric acidity and volume.

Author information

1
Department of Anesthesiology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari, Osaka, Japan.

Abstract

STUDY OBJECTIVE:

To investigate whether oral omeprazole 20 mg decreases the risk of aspiration pneumonia in patients with gastric tube reconstruction.

DESIGN:

Consecutive study.

SETTING:

Operation room of cancer center.

PATIENTS:

Thirteen patients with gastric tube reconstruction for esophageal cancer.

INTERVENTIONS:

Oral omeprazole 20 mg was given the night before surgery. A rapid-sequence induction with cricoid pressure was employed for induction of anesthesia. After tracheal intubation, a nasogastric catheter was inserted into the gastric tube and the contents were aspirated.

MEASUREMENTS AND MAIN RESULTS:

The pH and volume of the gastric contents were measured. The pH and volume of the gastric tube contents were 4.5 +/- 1.6 (range from 2.5 to 7.0) and 9.5 +/- 10.2 mL (range from 0 to 30 mL), respectively. Food residue was recognized in nine patients. There was no patient with a pH below 2.5 and a volume of 25 mL or greater.

CONCLUSIONS:

Omeprazole 20 mg decreased the acidity and volume of the gastric tube contents and reduced the risk of aspiration pneumonia in patients with a gastric tube in place.

PMID:
11498319
DOI:
10.1016/s0952-8180(01)00289-6
[Indexed for MEDLINE]

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