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Curr Opin Immunol. 2001 Aug;13(4):471-8.

CD1-specific T cells in microbial immunity.

Author information

1
Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Smith Building, Room 518, Boston, MA 02115, USA. jgumperz@rics.bwh.harvard.edu

Abstract

Recent results strengthen evidence that CD1-restricted T cells play important roles in host defense against microbial infections. Human subjects recently infected with Mycobacterium tuberculosis showed elevated responses to CD1c-mediated presentation of a microbial lipid antigen, compared with control donors. Activation of CD1d-restricted NKT cells with a synthetic glycolipid antigen results in improved immune responses to several infectious pathogens.

PMID:
11498304
DOI:
10.1016/s0952-7915(00)00243-0
[Indexed for MEDLINE]

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