Audiogenic seizure susceptibility in thyroid hormone receptor beta-deficient mice

Neuroreport. 2001 Aug 8;12(11):2359-62. doi: 10.1097/00001756-200108080-00015.

Abstract

As early-onset hypothyroidism produces audiogenic seizure susceptibility (AGS) in rodents, the role of TR alpha 1 and TR beta thyroid hormone receptors in AGS was investigated. AGS occurs in mice lacking specifically TR beta (Thrb(tm1/tm1)) and is marked by early onset and persistence, thereby differing from mouse strains where AGS is age-restricted. Thrb(tm1/tm1) mice display AGS whether on a mixed 129/Sv x C57BL/6J or congenic C57BL/6J background. 27% of wild-type mice on the mixed and 0% on the congenic background exhibited AGS. The inability of Thrb(tm1/tm1) mice to downregulate the response to sustained acoustic stimulation may reside in the brain or in the auditory system itself as Thrb(tm1/tm1) mice also display auditory deficits. The AGS phenotype identifies a novel neurological role for TR beta.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Age of Onset
  • Animals
  • Auditory Pathways / physiopathology*
  • Epilepsy, Reflex / physiopathology*
  • Hypothyroidism / physiopathology
  • Mice
  • Mice, Congenic
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Receptors, Thyroid Hormone / genetics*
  • Receptors, Thyroid Hormone / metabolism*

Substances

  • Receptors, Thyroid Hormone