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Microbiology. 2001 Aug;147(Pt 8):2021-8.

A highly polymorphic degenerate microsatellite for molecular strain typing of Candida krusei.

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Department of Molecular Microbiology, B. Rappaport Faculty of Medicine, Rambam Medical Center, Haifa 31096, Israel.


Simple sequence repeats, due to their high variability, are widely used for molecular epidemiology of pathogenic micro-organisms. However, their usefulness is restricted by their high instability and low information content. Here, a locus, CKTNR, in the fungal pathogen Candida krusei is described which displays considerable sequence, as well as length, heterogeneity. Alleles of this locus, which contains a degenerate trinucleotide repeat, appear to be stable. The CKTNR polymorphism could serve as the basis for a molecular typing system of C. krusei. Furthermore, analysis of the CKTNR allele distribution suggested that C. krusei reproduces mainly clonally.

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