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Curr Opin Struct Biol. 2001 Aug;11(4):458-63.

The design of self-replicating helical peptides.

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1
Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA.

Abstract

The self-assembly of helical peptides and information transfer through autocatalysis and cross-catalysis are the foundation of peptide-based molecular evolution models. Many fundamental properties of living systems, such as environmental sensitivity, chiroselectivity, cross-catalysis, dynamic error correction and conditional selection, are exhibited by various self-replicating peptide systems. Recently, advances have been made in the design of peptide systems with autocatalytic and cross-catalytic properties.

PMID:
11495739
[Indexed for MEDLINE]
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