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Curr Opin Struct Biol. 2001 Aug;11(4):427-32.

High-resolution structures and dynamics of membrane protein--lipid complexes: a critique.

Author information

1
IBS, UMR 5075 CEA-CNRS-UJF, F-38027 Grenoble Cedex 1, France. pebay@ibs.fr

Abstract

Crystallographic analysis of lipidic components in complex with membrane proteins reveals molecules exhibiting well-ordered polar or hydrophobic moieties in contact with protein. As dynamic methods indicate high exchange rates, the interpretation of structural data requires a detailed knowledge of the specificity, affinity and cooperativity of lipid binding.

PMID:
11495734
DOI:
10.1016/s0959-440x(00)00228-1
[Indexed for MEDLINE]

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