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J Consult Clin Psychol. 2001 Jun;69(3):511-5.

Influences of gender and weight gain on short-term relapse to smoking in a cessation trial.

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  • 1Center for Behavioral and Preventive Medicine, Brown University School of Medicine, Miriam Hospital, Providence, Rhode Island 02903, USA.


Few researchers have studied whether weight gain has an impact on short-term relapse to smoking. The authors of this study investigated predictors of relapse among 989 participants (60% women) in a randomized, double-blind, 10-week multicenter trial to determine the effect of fluoxetine (30 or 60 mg) versus placebo in combination with behavioral counseling for smoking cessation. Medication compliance and smoking status were biochemically verified. At Visit 2, participants were asked to set a quit date within the subsequent 2 visits. A proportional hazards regression model was used to predict risk of relapse within the first 3 months of quitting. Weight gain predicted relapse, but for men only. Female gender also predicted relapse. The results led the authors to question whether postcessation weight gain interventions should be restricted to women smokers.

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