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Aust N Z J Public Health. 2001 Jun;25(3):203-11.

Passive smoking and lung cancer: a cumulative meta-analysis.

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1
Department of Public Health and Community Medicine, Faculty of Medicine, The University of Sydney, New South Wales. richardt@health.usyd.edu.au

Abstract

OBJECTIVE:

To review the epidemiological evidence for the association between passive smoking and lung cancer.

METHOD:

Primary studies and meta-analyses examining the relationship between passive smoking and lung cancer were identified through a computerised literature search of Medline and Embase, secondary references, and experts in the field of passive smoking. Primary studies meeting the inclusion criteria were meta-analysed.

RESULTS:

From 1981 to the end of 1999 there have been 76 primary epidemiological studies of passive smoking and lung cancer, and 20 meta-analyses. There were 43 primary studies that met the inclusion criteria for this meta-analysis; more studies than previous assessments. The pooled relative risk (RR) for never-smoking women exposed to environmental tobacco smoke (ETS) from spouses, compared with unexposed never-smoking women was 1.29 (95% CI 1.17-1.43). Sequential cumulative meta-analysed results for each year from 1981 were calculated: since 1992 the RR has been greater than 1.25. For Western industrialised countries the RR for never-smoking women exposed to ETS compared with unexposed never-smoking women, was 1.21 (95% CI 1.10-1.33). Previously published international spousal meta-analyses have all produced statistically significant RRs greater than 1.17.

CONCLUSIONS:

The abundance of evidence in this paper, and the consistency of findings across domestic and workplace primary studies, dosimetric extrapolations and meta-analyses, clearly indicates that non-smokers exposed to ETS are at increased risk of lung cancer.

IMPLICATIONS:

The recommended public health policy is for a total ban on smoking in enclosed public places and work sites.

[Indexed for MEDLINE]

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