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Muscle Nerve. 2001 Sep;24(9):1219-24.

Recovery from fatigue in fast and slow single intact skeletal muscle fibers from aging mouse.

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Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina 27157, USA.


In the present work, we studied the recovery from fatigue (RF) of single intact fast- and slow-twitch muscle fibers from young (age 5--7 months) and old (age 22--24 months) mice. To examine whether differences in RF underlie decreases in muscle strength and endurance with aging, we performed in vitro experiments in manually dissected extensor digitorum longus (EDL) and soleus muscle fibers. We measured the recovery of the maximum force every 5 min for a total period of 30 min after inducing fiber fatigue. Fibers were classified, according to the fatigue index, into the following three groups: 0.75--0.99, 0.5--0.74, and <0.5. Although the tetanic tension of EDL and soleus fibers from young and old mice recovered significantly, no statistically significant difference in tension or recovery time was observed between age groups. These data support the concept that the reported decline in muscle force and endurance with aging is not related to changes in RF of individual muscles fibers.

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