Format

Send to

Choose Destination
See comment in PubMed Commons below
Best Pract Res Clin Gastroenterol. 2001 Aug;15(4):681-90.

Sclerosing cholangitis in the paediatric patient.

Author information

1
Paediatric Liver Service, Variety Club Children's Hospital, King's College Hospital, Denmark Hill, London SE5 9RS, UK. giorgina.vergani@kcl.ac.uk

Abstract

Sclerosing cholangitis in childhood is a heterogeneous condition, which has different aetiologies. Sclerosing cholangitis may be inherited and diagnosed in the neonatal period (neonatal sclerosing cholangitis); it may present later with features of autoimmunity (autoimmune sclerosing cholangitis); or it may be associated with a variety of disorders, including Langerhans cell histiocytosis, immunodeficiency, psoriasis, cystic fibrosis, reticulum cell sarcoma and sickle cell anaemia. In contrast to the experience in adult patients, sclerosing cholangitis occurring as an individual disease (primary sclerosing cholangitis) is rare. The initiating events and possible pathogenic mechanisms differ in the various forms of sclerosing cholangitis and are still obscure. Treatment and prognosis depend on the type of sclerosing cholangitis present.

PMID:
11492976
DOI:
10.1053/bega.2001.0213
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center