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J Control Release. 2001 Jul 6;74(1-3):27-30.

Tumor chronobiology.

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WJB Dorn VA Medical Center, and the School of Medicine and Norman J. Arnold School of Public Health of the University of South Carolina, Columbia, 29209, USA.


Traditionally, drug delivery has meant getting a simple chemical absorbed predictably from the gut or from the site of injection. A second-generation drug delivery goal has been the perfection of continuous constant rate (zero-order) delivery of simple xenobiotic molecules or common hormones. Living organisms are not 'zero-order' in their requirement for or response to drugs. They are predictable resonating dynamic systems, which require different amounts of drug at predictably different times within the circadian cycle in order to maximize desired and minimize undesired drug effects.

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