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Int J STD AIDS. 2001 Aug;12(8):532-4.

Lipid abnormalities in a healthcare worker receiving HIV prophylaxis.

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Division of Occupational Medicine, Department of Emergency Medicine, University of Pennsylvania Health System, One Silverstein Pavilion, 3400 Spruce Street, Philadelphia, PA 19104, USA.


Healthcare workers (HCWs) worldwide risk occupational exposure to HIV and other blood-borne pathogens. Post-exposure prophylaxis (PEP) may decrease the risk of seroconversion after occupational or sexual exposure. Current guidelines recommend immediate PEP with at least 2 drugs following HIV exposure. In high-risk exposures, the guidelines recommend the use of a protease inhibitor (PI) as well as 2 reverse transcriptase inhibitors. Protease inhibitors have been associated with dyslipidaemias, other metabolic abnormalities and lipodystrophy syndromes in AIDS patients. We report a case of new transient lipid abnormalities in a HCW receiving PEP after HIV exposure. HIV medications may produce occult metabolic abnormalities in HIV-negative individuals receiving PEP. This risk should be considered during follow-up evaluation for PEP.

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