Format

Send to

Choose Destination
Trends Genet. 2001 Aug;17(8):459-64.

MDM2: life without p53.

Author information

1
The Wellcome Trust and Cancer Research Campaign Institute of Cancer, Tennis Court Road, Cambridge, UK CB2 1QR.

Abstract

The MDM2 protein suppresses the ability of p53 to inhibit cellular proliferation or to induce cell death. This property underlies the oncogenic potential of MDM2, which is overexpressed in various human tumours. However, MDM2 also has p53-independent activities, which we focus on here. Similar to other oncogenes, surveillance pathways might counteract the deleterious effects of deregulated MDM2 expression. These pathways need to be inactivated for MDM2 oncogenic activity, which targets p53 but also other proteins.

PMID:
11485818
DOI:
10.1016/s0168-9525(01)02369-1
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center