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Am J Obstet Gynecol. 2001 Jul;185(1):220-6.

Survival, morbidity, and resource use of infants of 25 weeks' gestational age or less.

Author information

1
Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada.

Abstract

OBJECTIVE:

The objective of this study was to examine survival, morbidity, and resource use in a large cohort of extremely preterm infants.

STUDY DESIGN:

We examined all (n = 754) neonatal intensive care unit admissions born at < or =25 weeks' gestation and inborn deliveries (n = 949) between 22 and 25 weeks' gestation at 17 Canadian neonatal intensive care units.

RESULTS:

The overall survival rate was 63%, with a range from 14% at 22 weeks' gestation to 76% at 25 weeks' gestation. There was a high incidence of chronic lung disease (33%-51%), > or =grade 3 intraventricular hemorrhage (0%-16%), necrotizing enterocolitis (0%-14%), > or =stage 3 retinopathy of prematurity (27%-55%), nosocomial infection (25%-39%), and multiple gestation (18%-46%). Extremely preterm infants comprise 4% of neonatal intensive care unit admissions but account for 22% of deaths, 20%-60% of major morbidities, 11% of patient days, and 10%-35% of major procedures. Outborn infants had a higher incidence of chronic lung disease, severe retinopathy of prematurity, and intraventricular hemorrhage.

CONCLUSION:

Extremely preterm infants have a high incidence of mortality and morbidity and consume disproportionate amounts of neonatal intensive care unit resources.

PMID:
11483932
DOI:
10.1067/mob.2001.115280
[Indexed for MEDLINE]

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