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Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9907-12. Epub 2001 Jul 31.

Ethanol hypersensitivity and olfactory discrimination defect in mice lacking a homolog of Drosophila neuralized.

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1
Departments of Physiology and Biochemistry, Howard Hughes Medical Institute, University of California, San Francisco 94143, USA.

Abstract

Neurogenic genes in the Notch receptor-mediated signaling pathway play important roles in neuronal cell fate specification as well as neuronal differentiation. The Drosophila neuralized gene is one of the neurogenic genes. We have cloned a mouse homolog of Drosophila neuralized, m-neu1, and found that the m-neu1 transcript is expressed in differentiated neurons. Mice deficient for m-neu1 are viable and morphologically normal, but exhibit specific defects in olfactory discrimination and hypersensitivity to ethanol. These findings reveal an essential role of m-neu1 in ensuring proper processing of certain information in the adult brain.

PMID:
11481456
PMCID:
PMC55551
DOI:
10.1073/pnas.171321098
[Indexed for MEDLINE]
Free PMC Article
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