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Am J Psychiatry. 2001 Aug;158(8):1319-21.

Sensory gating deficit expressed by a disturbed suppression of the P50 event-related potential in patients with Alzheimer's disease.

Author information

1
Department of Psychiatry, University of Bonn, Sigmind-Freud-Str. 25, 53105 Bonn, Germany. jessen@uni-bonn.de

Abstract

OBJECTIVE:

Disturbed sensory gating has been related to attention deficit and greater distractibility in patients with schizophrenia, and dysfunction of the alpha-7 subunit of the cholinergic nicotinic receptor has been discussed as its biological basis. Alzheimer's disease is characterized by a cholinergic deficit, and postmortem studies have reported alpha-7 receptor loss in patients with Alzheimer's disease. In this study, the authors tested whether sensory gating is disturbed in patients with Alzheimer's disease.

METHOD:

Suppression of the P50 event-related potential following the second click of a double-click paradigm, a measure of sensory gating, was assessed in 17 Alzheimer's disease patients and 17 comparison subjects.

RESULTS:

Alzheimer's disease patients showed less P50 suppression following the second click relative to the comparison subjects.

CONCLUSIONS:

Disturbed sensory gating might result from cholinergic dysfunction and possibly from alpha-7 nicotinic receptor loss in patients with Alzheimer's disease. Prospective studies should investigate the relationship between sensory gating deficit and behavioral disturbances in Alzheimer's disease patients.

PMID:
11481170
DOI:
10.1176/appi.ajp.158.8.1319
[Indexed for MEDLINE]
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