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J Antibiot (Tokyo). 2001 May;54(5):415-20.

S-15183a and b, new sphingosine kinase inhibitors, produced by a fungus.

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Pharmacology and Molecular Biology Research Laboratories, Research Institute, Sankyo Co, Ltd, Shinagawa, Tokyo, Japan.


In the course of our screening for inhibitors of sphingosine kinase, we found two active compounds in a culture broth of a fungus, Zopfiella inermis SANK 15183. The structures of the compounds, named S-15183a and b, were elucidated by a combination of spectroscopic analyses to be new azaphilone-type metabolites. S-15183a and b inhibited sphingosine kinase from rat liver with IC50 values of 2.5 and 1.6 microM, respectively. S-15183a also inhibited endogenous SPH kinase activity in intact platelets.

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