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Arch Microbiol. 2001 Jul;176(1-2):155-7.

The role of the natural polyamine putrescine in defense against oxidative stress in Escherichia coli.

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Russian Academy of Sciences, Institute of Ecology and Genetics of Microorganisms, Golev St. 13, Perm, 614081, Russia.


Putrescine up-regulated, in a concentration-dependent manner, the expression levels of the oxyR and katG genes of Escherichia coli cells exposed to hydrogen peroxide. Its stimulatory effect was more pronounced under conditions of strong oxidative stress. 1,4-Diamino-2-butanone, a specific inhibitor of putrescine synthesis, also inhibited oxyR expression under oxidative stress. When added to inhibited cells, putrescine relieved this inhibitory effect. Addition of putrescine to E. coli cultures exposed to oxidative stress led to increased cell survival.

[Indexed for MEDLINE]

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