Format

Send to

Choose Destination
Arch Microbiol. 2001 Jul;176(1-2):155-7.

The role of the natural polyamine putrescine in defense against oxidative stress in Escherichia coli.

Author information

1
Russian Academy of Sciences, Institute of Ecology and Genetics of Microorganisms, Golev St. 13, Perm, 614081, Russia. agtkachenko@ecology.psu.ru

Abstract

Putrescine up-regulated, in a concentration-dependent manner, the expression levels of the oxyR and katG genes of Escherichia coli cells exposed to hydrogen peroxide. Its stimulatory effect was more pronounced under conditions of strong oxidative stress. 1,4-Diamino-2-butanone, a specific inhibitor of putrescine synthesis, also inhibited oxyR expression under oxidative stress. When added to inhibited cells, putrescine relieved this inhibitory effect. Addition of putrescine to E. coli cultures exposed to oxidative stress led to increased cell survival.

PMID:
11479716
DOI:
10.1007/s002030100301
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center