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Nat Med. 2001 Aug;7(8):947-53.

The adipocyte-secreted protein Acrp30 enhances hepatic insulin action.

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1
Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, USA.

Abstract

Acrp30 is a circulating protein synthesized in adipose tissue. A single injection in mice of purified recombinant Acrp30 leads to a 2-3-fold elevation in circulating Acrp30 levels, which triggers a transient decrease in basal glucose levels. Similar treatment in ob/ob, NOD (non-obese diabetic) or streptozotocin-treated mice transiently abolishes hyperglycemia. This effect on glucose is not associated with an increase in insulin levels. Moreover, in isolated hepatocytes, Acrp30 increases the ability of sub-physiological levels of insulin to suppress glucose production. We thus propose that Acrp30 is a potent insulin enhancer linking adipose tissue and whole-body glucose metabolism.

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PMID:
11479628
DOI:
10.1038/90992
[Indexed for MEDLINE]
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