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Isr J Psychiatry Relat Sci. 2001;38(2):133-6.

LSD-induced Hallucinogen Persisting Perception Disorder treated with clonazepam: two case reports.

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  • 1Lev Hasharon Mental Health Medical Center, Pardessya, Israel.


Benzodiazepines are recommended for the treatment of Hallucinogen Persisting Perception Disorder (HPPD), although it is unclear which may be more helpful. Two out-patients with LSD-induced HPPD were successfully treated with clonazepam. They had not responded to low potency benzodiazepines or low doses of classic antipsychotics. After clonazepam discontinuation they reported a marked improvement and only mild symptomatology which persisted during a six month follow-up period. High potency benzodiazepines like clonazepam, which has serotonergic properties, may be superior to low-potency benzodiazepines in the treatment of some patients with LSD-induced HPPD.

[PubMed - indexed for MEDLINE]
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