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J Nat Prod. 2001 Jul;64(7):993-6.

Suppressors of cancer cell proliferation from fig (Ficus carica) resin: isolation and structure elucidation.

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  • 1Department of Medicinal Chemistry and Natural Products, School of Pharmacy, The Hebrew University, Jerusalem 91120, Israel.

Abstract

A mixture of 6-O-acyl-beta-D-glucosyl-beta-sitosterols, the acyl moeity being primarily palmitoyl and linoleyl with minor amounts of stearyl and oleyl, has been isolated as a potent cytotoxic agent from fig (Ficuscarica) latex and soybeans. Identity was established by spectroscopic methods (NMR, MS) and confirmed by chemical synthesis. Both the natural and the synthetic compounds showed in vitro inhibitory effects on proliferation of various cancer cell lines.

PMID:
11473446
[PubMed - indexed for MEDLINE]
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