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Mech Dev. 2001 Aug;106(1-2):133-6.

Selective expression of angiopoietin 1 and 2 in mesenchymal cells surrounding veins and arteries of the avian embryo.

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Institut d'Embryologie Cellulaire et Moléculaire CNRS FRE 2160, 49bis, Avenue de la Belle Gabrielle, 94736 Cedex, Nogent-sur-Marne, France.


The expression of angiopoietin1 and 2 (ang1 and 2) and their receptor tie-2 was studied in avian embryos using in situ hybridization. Ang1 was transcribed in the mesenchymal cells surrounding venous endothelium expressing tie-2. By contrast, ang2 was transcribed around arteries in which the endothelium down-regulated tie-2 mRNA. The aorta and large arteries of the heart outflow tract were never surrounded by ang2 positive cells and maintained tie-2 expression.

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