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Aliment Pharmacol Ther. 2001 Aug;15(8):1177-85.

There are some benefits for eradicating Helicobacter pylori in patients with non-ulcer dyspepsia.

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Department of Hépato-Gastroentérologie, CHU de Nantes, Nantes, France.



The relationship between Helicobacter pylori infection and non-ulcer dyspepsia is not established.


To determine whether eradication of H. pylori might be of benefit in non-ulcer dyspepsia patients.


We randomly assigned 129 H. pylori infected patients with severe epigastric pain, without gastro-oesophageal reflux symptoms, to receive twice daily treatment with 300 mg of ranitidine, 1000 mg of amoxicillin, and 500 mg of clarithromycin for 7 days and 124 such patients to receive identical-appearing placebos.


Treatment was successful (decrease of symptoms at 12 months) in 62% of patients in the active-treatment group and in 60% of the placebo group (N.S.). At 12 months, the rate of eradication of H. pylori was 69% in the active-treatment group and 18% in the placebo group (P < 0.001). Complete relief of symptoms occurred significantly more frequently in patients on the active treatment (43%) than in placebo-treated patients (31%, P=0.048). Within the active-treatment group, therapeutic success was significantly more frequent in the non-infected patients (84% vs. 64%, P=0.04).


Although eradicating H. pylori is not likely to relieve symptoms in the majority of patients with non-ulcer dyspepsia, a small proportion of H. pylori-infected patients may benefit from eradication treatment.

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