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Acta Anaesthesiol Scand. 2001 Aug;45(7):914-8.

Anticoagulation with hirudin for continuous veno-venous hemodialysis in liver transplantation.

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Department of General and Transplantation Surgery, University Hospital Essen, Germany.


Postoperative encephalopathy after orthotopic liver transplantation can be difficult to diagnose. We report a case of heparin-induced thrombocytopenia in a liver transplant patient who had seizures. Due to poor liver function the patient developed hepatorenal syndrome requiring continuous veno-venous hemodialysis (CVVHD). Initially we used heparin as the anticoagulant. After the diagnosis of heparin-induced thrombocytopenia (HIT) was made, we switched to r-hirudin. No serious side effects, e.g. bleeding or immune sensitization, were seen.

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