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J Med Chem. 2001 Aug 2;44(16):2675-8.

(-)3-[4-[2-(Phenoxazin-10-yl)ethoxy]phenyl]-2-ethoxypropanoic acid [(-)DRF 2725]: a dual PPAR agonist with potent antihyperglycemic and lipid modulating activity.

Author information

1
Discovery Synthesis and Discovery Biology, Dr. Reddy's Research Foundation, 7-1-27, Ameerpet, Hyderabad 500 016, India.

Abstract

(-)DRF 2725 (6) is a phenoxazine analogue of phenyl propanoic acid. Compound 6 showed interesting dual activation of PPAR alpha and PPAR gamma. In insulin resistant db/db mice, 6 showed better reduction of plasma glucose and triglyceride levels as compared to rosiglitazone. Compound 6 has also shown good oral bioavailability and impressive pharmacokinetic characteristics. Our study indicates that 6 has great potential as a drug for diabetes and dyslipidemia.

PMID:
11472221
DOI:
10.1021/jm010143b
[Indexed for MEDLINE]

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