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Ann Clin Biochem. 2001 Jul;38(Pt 4):329-32.

Reference intervals for thyroid hormones in pregnant Chinese women.

Author information

1
Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR. nspanesar@cuhk.edu.hk

Abstract

OBJECTIVE:

To establish gestation-related reference intervals for thyroid hormones in a Chinese population.

MATERIALS AND METHODS:

A prospective study with 343 healthy pregnant women (5-41 weeks) and 63 non-pregnant controls. Thyroid stimulating hormone (TSH), free thyroxine (T4) and tri-iodothyronine (T3) (and human chorionic gonadotrophin) were measured by immunoassays. The median, 2.5th and 97.5th percentiles at 4-week intervals were calculated. Data were also analysed for significant trends using ANOVA.

RESULTS:

Free T3 decreased during pregnancy, whereas free T4 initially increased, peaking between 9-13 weeks and then decreased, the decline becoming significant by week 21. TSH mirrored changes in free T4.

CONCLUSION:

The gestation-related reference intervals for thyroid hormones should alleviate the misinterpretation of thyroid function in pregnancy.

PMID:
11471873
DOI:
10.1258/0004563011900830
[Indexed for MEDLINE]

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