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Obstet Gynecol Surv. 2001 Jun;56(6):361-76.

Androgens in postmenopausal women: production, possible role, and replacement options.

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1
Department of Obstetrics and Gynecology, Columbia University College of Physicians & Surgeons, Columbia Presbyterian Medical Center, New York, NY 10032-7302, USA.

Abstract

The physiology of normal androgen production in women has not been well understood. Aging, per se, accounts for much of the reduction in both ovarian and adrenal androgen production; and natural menopause does not result in an abrupt decline in testosterone production. Therefore, the definition of an androgen deficiency state in women, in the absence of adrenal suppression and/or bilateral oophorectomy, has been difficult. Nevertheless there are well-documented beneficial effects of androgen on many organ systems, including bone and the brain. This review focuses on the physiology of androgens in postmenopausal women and includes a discussion of the definition of an androgen deficiency state, the anticipated effects of androgen on several parameters of health, and possible ways in which androgens may be administered to women.

[Indexed for MEDLINE]

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