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Science. 2001 Jul 20;293(5529):465-8.

Impact of polymer tether length on multiple ligand-receptor bond formation.

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1
Materials Research Laboratory, Department of Chemical Engineering, University of California, Santa Barbara, CA 93106, USA.

Abstract

The promoters of cell adhesion are ligands, which are often attached to flexible tethers that bind to surface receptors on adjacent cells. Using a combination of Monte Carlo simulations, diffusion reaction theory, and direct experiments (surface force measurements) of the biotin-streptavidin system, we have quantified polymer chain dynamics and the kinetics and spatial range of tethered ligand-receptor binding. The results show that the efficiency of strong binding does not depend solely on the molecular architecture or binding energy of the receptor-ligand pair, nor on the equilibrium configuration of the polymer tether, but rather on its "rare" extended conformations.

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PMID:
11463908
DOI:
10.1126/science.293.5529.465
[Indexed for MEDLINE]
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