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BMJ. 2001 Jul 21;323(7305):142-6.

Relation between insufficient response to antihypertensive treatment and poor compliance with treatment: a prospective case-control study.

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1
Outpatient Department of Internal Medicine, University Hospital, CH-4031 Basle, Switzerland.

Abstract

OBJECTIVES:

To prospectively compare compliance with treatment in patients with hypertension responsive to treatment versus patients with treatment resistant hypertension.

DESIGN:

Prospective case-control study.

SETTING:

Outpatient department in a large city hospital in Switzerland, providing primary, secondary, and tertiary care.

PARTICIPANTS:

110 consecutive medical outpatients with hypertension and taking stable treatment with at least two antihypertensive drugs for at least four weeks.

MAIN OUTCOME MEASURES:

Treatment compliance assessed with MEMS devices; blood pressure determined by 12 hour daytime ambulatory monitoring (pressure <135/85 mm Hg in patients aged </=60 years and <155/90 mm Hg in patients aged >60 indicated hypertension responsive to treatment).

RESULTS:

Complete data were available for 103 patients, of whom 86 took >/=80% of their prescribed doses ("compliant") and 17 took <80% ("non-compliant"). Of the 49 patients with treatment resistant hypertension, 40 (82%) were compliant, while 46 (85%) of the 54 patients responsive to treatment were compliant.

CONCLUSION:

Non-compliance with treatment was not more prevalent in patients with treatment resistant hypertension than in treatment responsive patients.

PMID:
11463685
PMCID:
PMC34727
[Indexed for MEDLINE]
Free PMC Article
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