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Int J Antimicrob Agents. 2001 Jul;18(1):89-91.

Effect of cyclosporin on uropathogenic Escherichia coli adherence to human endothelial cells.

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Institute of Microbiology and Infectious Diseases, Karol Marcinkowski University of Medical Sciences in Poznan, Wieniawskiego 3, 61-712, Poznan, Poland.


The effect of cyclosporin A on the adherence of Escherichia coli strains to human umbilical vein endothelial cells was studied. Compared with the controls, bacterial adherence significantly increased following preincubation of the cells with cyclosporin A at 50 mg/l and more significantly, to cells preincubated with cyclosporin A at 100-200 mg/l. The results showed that cyclosporin A use may be accompanied by an increased bacterial adherence to host cells in vivo. This effect was achieved using a wide range of therapeutic doses.

[Indexed for MEDLINE]

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