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J Virol. 2001 Aug;75(16):7774-7.

Role for p53 in gene induction by double-stranded RNA.

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1
Greenebaum Cancer Center, The University of Maryland, Baltimore, Maryland 21201, USA.

Abstract

Cross talk between p53 and interferon-regulated pathways is implicated in the induction of gene expression by biologic and genotoxic stresses. We demonstrate that the interferon-stimulated gene ISG15 is induced by p53 and that p53 is required for optimal gene induction by double-stranded RNA (dsRNA), but not interferon. Interestingly, virus induces ISG15 in the absence of p53, suggesting that virus and dsRNA employ distinct signaling pathways.

PMID:
11462054
PMCID:
PMC115017
DOI:
10.1128/JVI.75.16.7774-7777.2001
[Indexed for MEDLINE]
Free PMC Article
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